Recent Publications on LCGC Libraries and Approaches
- Donover PS, Yohn M, Sim M, Wright A, Gowda S, Allee C, Reichman M (2012). New informatics and automated infrastructure to accelerate new leads discovery by high throughput screening (HTS). Comb Chem & HTS (In Press).
- Reichman M and Gill H. (2008) Automated drug screening for ADMET properties, Drug Metabolism Handbook: Concepts and Applications,p. 127-66. Nassar AF, Hollenberg PF, Scatina J. (Eds). John Wiley & Sons Inc, Hoboken, NJ.
- Thompson S, Messick T, Schultz DC, Reichman M, Lieberman PM (2010). Development of a high-throughput screen for inhibitors of Epstein-Barr virus EBNA1 Jour of Biomol Screen. 15(9):1107-15.
Recent Poster Presentations
- LCGC SBS ORLANDO 2011 POSTER – from the 17th Annual SLAS/SBS Drug Discovery Meeting in Orlando, FL
- Targeting Glycation as a Treatment for Diabetes Complications – from the 17th Annual SLAS/SBS Drug Discovery Meeting in Orlando, FL
Background Information about Orthogonal Pooled Screening (OPS)
- Motlekar N, Diamond SL, Napper AD (2008). Evaluation of an orthogonal pooling strategy for rapid high-throughput screening of proteases. Assay Drug Dev Technol. 6(3):395-405.
- Hughes-Oliver JM (2006). Pooling experiments for blood screening and drug discovery, Screening Methods for Experimentation in Industry, Drug Discovery, and Genetics, p.21-47. Dean A, Lewis S. (Eds). Springer.
- Ferrand S, Schmid A, Engeloch C, Glickman JF (2005). Statistical evaluation of a self-deconvoluting matrix strategy for high throughput screening of the CXCR3 receptor. Assay and Drug Development Technologies 3(4) 413-424.
- Devlin J, Lian A, Trinh L, Polokoff M, Senator D, Zheng W, Kondracki J, Kretschmer P, Morser J, Lipson S, Spann R, Loughlin J, Dunn K, Morrissey M (1996). High capacity screening of pooled compounds: identification of the active compound without re-assay of pool members. Drug Dev Res. 37:80–85.
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